PALMITOYL DIPEPTIDE-5 DIAMINO-HYDROXYBUTYRATE ●
TL;DR. This ingredient is a lipid-modified peptide used as a skin-conditioning active in leave-on formulas. Its main role is to support a smoother, firmer-looking skin appearance rather than to preserve, cleanse, or emulsify the product.
What does PALMITOYL DIPEPTIDE-5 DIAMINO-HYDROXYBUTYRATE do in a cosmetic formula?
This ingredient is a lipid-modified peptide used as a skin-conditioning active in leave-on formulas. Its main role is to support a smoother, firmer-looking skin appearance rather than to preserve, cleanse, or emulsify the product.
Is PALMITOYL DIPEPTIDE-5 DIAMINO-HYDROXYBUTYRATE clean?
Clean-beauty frameworks generally treat this ingredient as low concern for irritation at typical use levels, with no major restricted-list profile. The main caveat is that it is a highly processed synthetic active, so acceptance varies by standard and by documentation from the supplier.
Is PALMITOYL DIPEPTIDE-5 DIAMINO-HYDROXYBUTYRATE sustainable?
This material is made through peptide chemistry using amino-acid derivatives plus a fatty chain, which may come from palm, other vegetable oils, or petrochemical sources depending on the supplier. It is not known for the persistence concerns associated with silicones or fluorinated materials, but peptide manufacture can be solvent- and purification-intensive.
Is PALMITOYL DIPEPTIDE-5 DIAMINO-HYDROXYBUTYRATE COSMOS-approved?
This ingredient is not typically aligned with COSMOS-organic or COSMOS-natural unless a supplier can document compliant sourcing and processing, because it is a synthetically assembled, modified peptide. From a Green Chemistry view, it has a favorable use-at-low-level profile, but its multi-step synthesis and solvent demand are compromises.
How does PALMITOYL DIPEPTIDE-5 DIAMINO-HYDROXYBUTYRATE work chemically?
The molecule combines a C16 lipid tail with a short peptide-like polar head, improving compatibility with emulsions and helping the active associate with the skin surface. It is usually supplied in dilute blends for leave-on products and is best handled with moderate processing temperatures, compatible pH, and protection from strong oxidizers.
Last updated 2026-05-14