Sh-Polypeptide-123 ●
TL;DR. This ingredient is a skin-conditioning bioactive used as a signal-style peptide, usually included to support the look of firmness, smoothness, or recovery in leave-on formulas. It is typically used at very low levels inside serums, creams, and targeted treatments.
What does Sh-Polypeptide-123 do in a cosmetic formula?
This ingredient is a skin-conditioning bioactive used as a signal-style peptide, usually included to support the look of firmness, smoothness, or recovery in leave-on formulas. It is typically used at very low levels inside serums, creams, and targeted treatments.
Is Sh-Polypeptide-123 clean?
From a clean-beauty perspective, this ingredient is generally viewed as low-allergen and well-tolerated, but it can create standards friction because it is a highly processed biotechnology or lab-made active rather than a traditional natural material. The main scrutiny is usually claim substantiation, purity, and residual processing materials, not routine irritation.
Is Sh-Polypeptide-123 sustainable?
This material is typically made through biotechnology or peptide synthesis, which uses small inclusion levels but can involve purified feedstocks, solvents, and energy-intensive downstream processing. As a protein-like molecule, it is expected to break down into smaller peptide and amino-acid fragments rather than persist in the environment.
Is Sh-Polypeptide-123 COSMOS-approved?
This ingredient is not a straightforward fit for COSMOS organic or natural certification unless a supplier can document a permitted biotechnology route, compliant processing, and acceptable auxiliaries. From a Green Chemistry view, it has positives around low use level and biodegradability, with caveats around synthesis, purification burden, and non-agricultural sourcing.
How does Sh-Polypeptide-123 work chemically?
The molecule is a sequence-defined biomimetic chain of amino acids, so performance depends on purity, folding or conformation where relevant, and protection from proteases or harsh processing. It is normally added during cool-down in water-based systems, with formulators managing pH, preservatives, and chelators to support stability in finished products.
Last updated 2026-05-13